Jaclyn Goodrich, PhD
- M6226 SPH II
- 1415 Washington Heights
- Ann Arbor, Michigan 48109-2029
Dr. Jackie Goodrich is a Research Assistant Professor of Environmental Health Sciences at the University of Michigan School of Public Health. Dr. Goodrich completed her undergraduate degree in Cellular and Molecular Biology and her doctoral degree in Toxicology at the University of Michigan. She furthered her training with a postdoctoral fellowship at the University of Michigan focused on epigenetics and environmental epidemiology.
Dr. Goodrich's research interests combine toxicology, epidemiology and epigenomics with the goal of identifying epigenetically labile genomic regions that contribute to environmentally-induced disease susceptibility at various life-stages (in utero, early childhood, and adulthood). Epigenetic modification by environmental factors is emerging as a link between exposures to toxicity and disease outcomes. Dr. Goodrich is assessing the impact of chemical exposures from occupational practices or the environment (e.g., mercury, lead, phthalates) on epigenetic modifications (DNA methylation) in epidemiological cohorts from around the globe using both candidate gene and epigenome-wide approaches. She integrates data on exposures, DNA methylation, and health outcomes to better understand disease risk from exposures at vulnerable life-stages. Dr. Goodrich also studies the impact of environmental exposures, particularly to heavy metals such as lead and mercury, on cardiovascular and metabolic health outcomes. Dr. Goodrich works out of the Environmental Epigenetics and Nutrition lab.
B.S., Cellular and Molecular Biology, University of Michigan, 2007
Heavy metal toxicology
Developmental origins of health and disease
- Erinc A., Davis M.B., Padmanabhan V., Langen E.,† Goodrich J.M.†2021 Considering environmental exposures to per- and polyfluoroalkyl substances (PFAS) as risk factors for hypertensive disorders of pregnancy. Environmental Research. 197:111113. PMID: 33823190.
- Goodrich J.M., Furlong M.A., Caban-Martinez A.J., Jung A.M., Batai K., Jenkins T., Beitel S., Littau S., Gulotta J., Wallentine D., Hughes J., Popp C., Calkins M.M., Burgess J.L. 2021. Differential DNA methylation by Hispanic ethnicity among firefighters in the United States. Epigenetics Insights. doi: 1177/25168657211006159.
- Rotimi O.A., Onuzulu C.D., Dewald A.L., Ehlinger J., Adelani B.I., Olasehinde O.E., Rotimi S.O., Goodrich J.M. 2021. Early life exposure to aflatoxin B1 among rats: Alterations in lipids, hormones, and DNA methylation among the offspring. Gestational aflatoxin exposure and epigenetics. International Journal of Environmental Research and Public Health. 18(2):589. PMCID: PMC7828191.
- McCabe C.F., Padmanabhan V., Dolinoy D.C., Domino S.E., Jones T.R., Bakulski K., Goodrich J.M. Maternal Environmental Exposure to Bisphenols and Epigenome-Wide DNA Methylation in Infant Cord Blood. Environmental Epigenetics 6(1):dvaa012. PMCID: PMC7757124.
- Goodrich J.M.,† Hector E.C.,† Tang L., LaBarre J., Dolinoy D.C., Mercado-Garcia A., Cantoral A., Song, P.X.K., Tellez-Rojo M.M., Karen E. Peterson. 2020. Integrative analysis of gene-specific DNA methylation and untargeted metabolomics data from the ELEMENT cohort. Epigenetics Insights. doi: 10.1177/2516865720977888. PMCID: PMC7734565.
- Labarre J.L., McCabe C.F., Jones T.R., Song P.X.K., Domino S.E., Treadwell M.C., Dolinoy D.C., Padmanabhan V.†, Burant C.F.†, Goodrich J.M.† 2020. Maternal lipidome across pregnancy is associated with the neonatal DNA methylome. Epigenomics. 12(23):2077-2092. PMCID: PMC7857356.
- Jansen E.C., Dolinoy D.C.., Peterson K.E., O’Brien L., Chervin R., Cantoral A., Tellez-Rojo M.M., Goodrich J.M. 2020. Adolescent sleep timing and dietary patterns in relation to DNA methylation of core circadian genes: A pilot study of Mexican youth. Epigenetics. 4:1-14. PMID: 33016191.
- Montrose L.,† Goodrich J.M.,† Morishita M., Kochmanski , Klaver Z., Cavalcante R., Lumeng J.C., Peterson K.E., Dolinoy D.C. 2020. Neonatal Lead (Pb) Exposure and DNA Methylation in Dried Bloodspots. International Journal of Environmental Research and Public Health. 17(18):6775. PMCID: PMC7559513.
- Rygiel C., Dolinoy D.C., Perng W., Jones T.R., Solano M., Hu H., Téllez-Rojo M.M., Peterson K.E., Goodrich J.M. 2020. Trimester-specific associations of prenatal lead exposure with infant cord blood DNA methylation at birth. Epigenetics Insights. 13:2516865720938669. PMCID: PMC7372614.
- 10. Parajuli R.P.,† Goodrich J.M.,† Chou H.N., Gruninger S.E., Dolinoy D.C., Franzblau A., Basu N. 2016. Genetic polymorphisms are associated with hair, blood, and urine mercury levels in the American Dental Association (ADA) Study participants. Environmental Research. 149:247-258. PMCID: PMC4897752.
† Denotes equal contribution
Association for Clinical and Translational Science (ACTS)
Environmental Mutagenesis and Genomics Society (EMGS)
Society of Toxicology (SOT)