Faculty Profile

Brigid  Gregg, MD

Brigid Gregg, MD

  • Assistant Professor, Division of Pediatric Endocrinology
  • Assistant Professor, Nutritional Sciences
  • 1500 East Medical Center Drive, D1205 MPB
  • Ann Arbor, MI 48109

The focus of the Gregg lab is to understand how early life nutrient stressors can program offspring risk for obesity, diabetes and metabolic syndrome. We use both animal models and a human mother-infant cohort to understand the molecular events that set the stage for lifelong metabolic health. Our previous work helped establish the importance of early life for pancreatic beta-cell expansion. We are now studying the impact of nutrient stressors during the lactation period on the function of key tissues responsible for a coordinated response to glucose: the pancreatic islets, adipose tissue, and the liver. We also plan to examine the impact of maternal metabolic disease on lactation physiology.

  • Culinary Medicine at the University of Michigan Medical School

  • BS in Animal Physiology and Neuroscience, University of California San Diego, 1999
  • MD Case Western Reserve University, 2004
  • Residency in Pediatrics, University of Chicago, 2007
  • Fellowship in Pediatric Endocrinology, University of Chicago, 2010

  • Neonatal/childhood determinants of pancreatic beta-cell mass
  • Stimulus to burst of postnatal beta-cell replication
  • Perinatal programming of adult metabolic disease
  • Nutritional alterations during the lactation period and lactational programming of metabolic disease

  • Hafner H, Chang E, Carlson Z, Zhu A, Varghese M, Clemente J, Abrishami S, Bagchi DP, MacDougald OA, Singer K, Gregg B. Lactational High-Fat Diet Exposure Programs Metabolic Inflammation and Bone Marrow Adiposity in Male Offspring. Nutrients. 2019 Jun 21;11(6). pii: E1393. doi: 10.3390/nu11061393. PMID: 31234301
  • Ellsworth L, Harman E, Padmanabhan V, Gregg B. Lactational programming of glucose homeostasis: a window of opportunity. Reproduction. 2018 Aug;156(2):R23-R42. doi: 10.1530/REP-17-0780. Epub 2018 May 11. Review. PMID: 29752297
  • Gregg BE, Botezatu N, Brill JD, Hafner H, Vadrevu S, Satin LS, Alejandro EU, Bernal-Mizrachi E. Gestational exposure to metformin programs improved glucose tolerance and insulin secretion in adult male mouse offspring. Sci Rep. 2018 Apr 10;8(1):5745. doi: 10.1038/s41598-018-23965-4. PMID: 29636523
  • Booms S, Hill E, Kulhanek L, Vredeveld J, Gregg B. Iodine Deficiency and Hypothyroidism From Voluntary Diet Restrictions in the US: Case Reports. Pediatrics. 2016 Jun;137(6). pii: e20154003. doi: 10.1542/peds.2015-4003. Epub 2016 May 10. PMID: 27244854
  • Gregg B, Elghazi L, Alejandro EU, Smith MR, Blandino-Rosano M, El-Gabri D, Cras-Méneur C, Bernal-Mizrachi E. Exposure of mouse embryonic pancreas to metformin enhances the number of pancreatic progenitors. Diabetologia. 2014 Dec;57(12):2566-75. doi: 10.1007/s00125-014-3379-5. Epub 2014 Sep 24. PMID: 25249235
  • Gregg BE, Moore PC, Demozay D, Hall BA, Li M, Husain A, Wright AJ, Atkinson MA, Rhodes CJ. Formation of a human β-cell population within pancreatic islets is set early in life.  J Clin Endocrinol Metab. 2012 Sep;97(9):3197-206. doi: 10.1210/jc.2012-1206. Epub 2012 Jun 28. PMID: 22745242

  • American Diabetes Association
  • International Society for Research in Human Milk and Lactation
  • Developmental Origins of Health and Disease Society
  • Society for Pediatric Research